@Article{LopesOMOMTLM:2017:BiDiCa,
author = "Lopes, F. S. and Oliveira, J. R. and Milani, J. and Oliveira, L.
D. and Machado, Jo{\~a}o Paulo Barros and Trava Airoldi, Vladimir
Jesus and Lobo, A. O. and Marciano, F. R.",
affiliation = "{Universidade Brasil} and {Universidade Estadual Paulista (UNESP)}
and {Universidade do Vale do Para{\'{\i}}ba (UNIVAP)} and
{Universidade Estadual Paulista (UNESP)} and {Instituto Nacional
de Pesquisas Espaciais (INPE)} and {Instituto Nacional de
Pesquisas Espaciais (INPE)} and {Universidade Brasil} and
{Universidade Brasil}",
title = "Biomineralized diamond-like carbon films with incorporated
titanium dioxide nanoparticles improved bioactivity properties and
reduced biofilm formation",
journal = "Materials Science and Engineering C",
year = "2017",
volume = "81",
pages = "373--379",
month = "Dec.",
keywords = "Diamond-like carbonTitanium
dioxideNanoparticlesBiomineralizationHydroxyapatiteAntibacterial
activity.",
abstract = "Recently, the development of coatings to protect biomedical alloys
from oxidation, passivation and to reduce the ability for a
bacterial biofilm to form after implantation has emerged.
Diamond-like carbon films are commonly used for implanted medical
due to their physical and chemical characteristics, showing good
interactions with the biological environment. However, these
properties can be significantly improved when titanium dioxide
nanoparticles are included, especially to enhance the bactericidal
properties of the films. So far, the deposition of hydroxyapatite
on the film surface has been studied in order to improve
biocompatibility and bioactive behavior. Herein, we developed a
new route to obtain a homogeneous and crystalline apatite coating
on diamond-like carbon films grown on 304 biomedical stainless
steel and evaluated its antibacterial effect. For this purpose,
films containing two different concentrations of titanium dioxide
(0.1 and 0.3 g/L) were obtained by chemical vapor deposition. To
obtain the apatite layer, the samples were soaked in simulated
body fluid solution for up to 21 days. The antibacterial activity
of the films was evaluated by bacterial eradication tests using
Staphylococcus aureus biofilm. Scanning electron microscopy, X-ray
diffraction, Raman scattering spectroscopy, and goniometry showed
that homogeneous, crystalline, and hydrophilic apatite films were
formed independently of the titanium dioxide concentration.
Interestingly, the diamond-like films containing titanium dioxide
and hydroxyapatite reduced the biofilm formation compared to
controls. A synergism between hydroxyapatite and titanium dioxide
that provided an antimicrobial effect against opportunistic
pathogens was clearly observed.",
doi = "10.1016/j.msec.2017.07.043",
url = "http://dx.doi.org/10.1016/j.msec.2017.07.043",
issn = "0928-4931",
language = "en",
targetfile = "lopes_biomineralized.pdf",
urlaccessdate = "27 abr. 2024"
}